What is Acne Vulgaris?
Acne vulgaris is a common chronic skin disease involving blockage and/or inflammation of pilosebaceous units (hair follicles and their accompanying sebaceous gland). Acne can present as noninflammatory lesions, inflammatory lesions, or a mixture of both, affecting mostly the face but also the back and chest.
Typical features of the condition include blackheads or whiteheads, pimples, oily skin, and possible scarring. It primarily affects skin with a relatively high number of oil glands, including the face, upper part of the chest, and back. The resulting appearance can lead to anxiety, reduced self-esteem, and, in extreme cases, depression or thoughts of suicide.
Genetics is the primary cause of acne in 80% of cases. The role of diet and cigarette smoking in the condition is unclear, and neither cleanliness nor exposure to sunlight appears to play a part. In both sexes, hormones called androgens appear to be part of the underlying mechanism, by causing increased production of sebum. Another common factor is the excessive growth of the bacterium Cutibacterium acnes, which is present on the skin.
Classification of Acne
Comedones are sebaceous plugs impacted within follicles. They are termed open or closed depending on whether the follicle is dilated or closed at the skin surface. Plugs are easily extruded from open comedones but are more difficult to remove from closed comedones. Closed comedones are the precursor lesions to inflammatory acne.
Papules and pustules occur when P. acnes colonizes the closed comedones, breaking down sebum into free fatty acids that irritate the follicular epithelium and eliciting an inflammatory response by neutrophils and then lymphocytes, which further disrupts the epithelium. The inflamed follicle ruptures into the dermis (sometimes precipitated by physical manipulation or harsh scrubbing), where the comedone contents elicit a further local inflammatory reaction, producing papules. If the inflammation is intense, grossly purulent pustules occur.
Nodules and cysts are other manifestations of inflammatory acne. Nodules are deeper lesions that may involve > 1 follicle, and cysts are large fluctuant nodules.
The most common trigger is
During puberty, surges in androgen stimulate sebum production and hyperproliferation of keratinocytes.
Other triggers include
- Hormonal changes that occur with pregnancy or the menstrual cycle
- Occlusive cosmetics, cleansers, lotions, and clothing
- High humidity and sweating
Associations between acne exacerbation and diet, inadequate face washing, masturbation, and sex are unfounded. Some studies suggest a possible association with milk products and high-glycemic diets. Acne may abate in summer months because of sunlight’s anti-inflammatory effects. Proposed associations between acne and hyperinsulinism require further investigation. Some drugs and chemicals (eg, corticosteroids, lithium, phenytoin, isoniazid) worsen acne or cause acneiform eruptions.
Symptoms and Signs
Skin lesions and scarring can be a source of significant emotional distress. Nodules and cysts can be painful. Lesion types frequently coexist at different stages.
Comedones appear as whiteheads or blackheads. Whiteheads (closed comedones) are flesh-colored or whitish palpable lesions 1 to 3 mm in diameter; blackheads (open comedones) are similar in appearance but with a dark center.
Papules and pustules are red lesions 2 to 5 mm in diameter. Papules are relatively deep. Pustules are more superficial.
Nodules are larger, deeper, and more solid than papules. Such lesions resemble inflamed epidermoid cysts, although they lack true cystic structure.
Cysts are suppurative nodules. Rarely, cysts form deep abscesses. Long-term cystic acne can cause scarring that manifests as tiny and deep pits (icepick scars), larger pits, shallow depressions, or hypertrophic scarring or keloids.
Acne conglobata is the most severe form of acne vulgaris, affecting men more than women. Patients have abscesses, draining sinuses, fistulated comedones, and keloidal and atrophic scars. The back and chest are severely involved. The arms, abdomen, buttocks, and even the scalp may be affected.
Acne fulminans is acute, febrile, ulcerative acne, characterized by the sudden appearance of confluent abscesses leading to hemorrhagic necrosis. Leukocytosis and joint pain and swelling may also be present.
Pyoderma faciale (also called rosacea fulminans) occurs suddenly on the midface of young women. It may be analogous to acne fulminans. The eruption consists of erythematous plaques and pustules, involving the chin, cheeks, and forehead. Papules and nodules may develop and become confluent.
- Comedones: Topical tretinoin
- Mild inflammatory acne: Topical retinoid alone or with a topical antibiotic, benzoyl peroxide, or both
- Moderate acne: Oral antibiotic plus topical therapy as for mild acne
- Severe acne: Oral isotretinoin
- Cystic acne: Intralesional triamcinolone
It is important to treat acne to reduce the extent of disease, scarring, and psychologic distress.
Treatment of acne involves a variety of topical and systemic agents directed at reducing sebum production, comedone formation, inflammation, and bacterial counts and at normalizing keratinization (see Figure: How various drugs work in treating acne). Selection of treatment is generally based on severity; options are summarized in table Drugs Used to Treat Acne. See also guidelines of care for the management of acne vulgaris from the American Academy of Dermatology.
Affected areas should be cleansed daily, but extra washing, use of antibacterial soaps, and scrubbing confer no added benefit.
A lower glycemic diet and moderation of milk intake might be considered for treatment-resistant adolescent acne.
Peeling agents such as sulfur, salicylic acid, glycolic acid, and resorcinol can be useful therapeutic adjuncts but are no longer commonly used.
Oral contraceptives are effective in treating inflammatory and noninflammatory acne, and spironolactone (beginning at 50 mg po once/day, increased to 100 mg po once/day after a few mo if needed) is another anti-androgen that is occasionally useful in women. Various light therapies, with and without topical photosensitizers, have been used effectively, mostly for inflammatory acne.
Treatment should involve educating the patient and tailoring the plan to one that is realistic for the patient. Treatment failure can frequently be attributed to lack of adherence to the plan and also to lack of follow-up. Consultation with a specialist may be necessary.
EXCELLENT FORMULA OF THIS SUPPLEMENT ALLOWS IT TO TACKLE THE ROOT OF THE PROBLEM BY ELIMINATING THE SOURCE OF INFLAMMATION.
The treatment of skin lesions like acne should be based on the thorough understanding of the root of the problem. This is the idea that motivated the manufacturers of Nonacne to create a product based on a mix of unique, natural ingredients. The effectiveness of Nonacne’s ingredients has been proven in clinical trials. Their careful selection maximizes the potency of the supplement.
What is the secret of this innovative anti-acne product?
- Red Clover – thanks to many valuable elements contained in red clover, it helps reduce excess sebum, which is the primary cause of spots on the skin,
- Sarsaparilla – …an herb with antibacterial and antifungal properties, sarsaparilla reduces skin inflammation and helps to soothe wounds that are difficult to heal,
- Grape Seed Extract – contains oligomeric proanthocyanidins (OPCs), which have anti-inflammatory properties. Grape Seed Extract also contains antioxidants and has antihistamine properties, which in combination with linoleic acid, soften and smooth the skin and fill the space between cells to give skin a healthier overall appearance,
- Nettle Leaf – has strong anti-inflammatory, antiseborrhoeic and anti-acne properties. It activates the processes of skin and aids in tissue regeneration,
- Vitamin C – plays an important role in the reconstruction of the skin, in particular acne scars. It is also necessary for the production of collagen in the body, which makes the healing of wounds possible. Vitamin C is an antioxidant that inhibits the action of free radicals responsible for skin cell damage,
- Zinc – zinc deficiency in the body is a direct cause of the formation of acne, so its presence is extremely important for healthy skin.
NONACNE DOES NOT ONLY ELIMINATE THE SYMPTOMS OF ACNE, IT ALSO PREVENTS THE APPEARANCE OF NEW SKIN LESIONS.
Nonacne inhibits the excessive secretion of sebum, unblocks pores and works against skin inflammation. Thanks to these properties skin regains its healthy condition, and you do not have to worry about the red bumps on your face anymore! In addition, Nonacne helps prevent the appearance of new lesions on the face, such as papules, pustules, blackheads, or cysts, which are the result of inflammation.
Acne may also be caused by hormonal imbalance, in particular androgen imbalance as this hormone is responsible for skin problems. Nonacne, thanks to its structure and proper ingredients, can cope even with this problem. Nonacne effectively treats all types of acne, regardless of its sources! Acne has no chance against Nonacne!
Packaging: 60 capsules
|Red Clover||200 mg|
|Grape Seed Extract||200 mg|
|Nettle Leaf 4:1 Extract|
(whole leaf equivalent)
|Vitamin C||100 mg||125%*|
|Vitamin E||50 mg a-TE||417%*|
|Vitamin B5||20 mg||333%*|
|Vitamin B6||20 mg||1429%*|
|Vitamin A||130 µg RE||16%*|
DIRECTIONS OF USE
It is recommended to take 2 capsules a day.
WHAT MAKES NONACNE DIFFERENT?
- Nonacne has both active and preventive action – it removes existing spots and prevents the appearance of new lesions,
- helps get rid of pustules, reddening, pimples and other skin imperfections resulting from inflammation of the skin,
- it is effective in fighting acne caused by hormonal imbalance,
- leads to a clean, healthy complexion and improves the condition of facial skin,
- completely safe for your health,
- contains unique ingredients, the combination of which has never before been used in any other anti-acne product!
WHAT ARE THE BENEFITS OF NONACNE INGREDIENTS?
Red clover – (its Latin name means found in meadows) is a source of many valuable elements and one of the main methods used by herbalists to treat acne. Red clover is rich in daidzein, genistein and formononetin, salicylic acid, choline, methyl salicylate, calcium, potassium, zinc, phosphorus, molybdenum, vitamin B-3, C and E as well as beta-carotene. It contains isoflavones and acts as an estrogen to correct the hormonal imbalances that cause acne. Additionally, it is a strong antioxidant that cleanses the body of excess toxins.
Sarsaparilla – a herb derived from the roots of of greenbrier plans that was first used in South America and Asia. Today, these countries continue to use sarsaparilla as an effective method of treating skin ailments. The effectiveness of this herb has been confirmed in clinical trials – it has antibacterial and antifungal properties and effectively eliminates acne. It also reduces inflammation of the skin and is rich in valuable minerals, such as: iron, zinc, copper, iodine, manganese, silicon and vitamins C, A, B, D.
Grape seed extract – contains Vitamin E, flavonoids and linoleic acid, which help to protect collagen and elastin in cells. Linoleic acid softens and smoothes the skin, thus making it healthy and free of spots. Grape seeds also contain OPC, which is rich in antioxidants that neutralize free radicals in the body and slow down the aging process. Furthermore, OPC can effectively prevent the appearance of spots and keep skin healthy.
Nettle leaf extract – has laboratory-confirmed anti-inflammatory and antibacterial properties. It shows strong antioxidant and cleansing properties and neutralizes free radicals. Nettle inhibits the release of inflammatory prostaglandins COX-2, hinders the growth of bacteria and has a beneficial effect on skin by fighting diseases such as acne.Its antibacterial properties prevent the growth of both Gram-positive and Gram-negative bacteria, including E.coli.
Vitamin C – plays an essential role skin regeneration. Studies have confirmed that vitamin C can reduce irritation and redness associated with acne scars and acne. It also rebuilds damaged collagen, which is responsible for skin elasticity.
Some Real Customer Testimonials
For me, acne appeared quite suddenly and I was advised to use creams. But when I used the cream on some existing spots, new ones popped up in other places. I have read that in my case the treatment should not be limited to visible acne lesions only but it should embrace the whole skin. I decided to take care of the treatment myself and I bought Nonacne. I confirm its effectiveness – after a few days the pimples became smaller, faded and finally disappeared without a trace. I am even more happy now that I can enjoy sunny weather without hiding behind a baseball cup and a turtleneck.
– Heidi, Sheffield
I’ve always had problems choosing an appropriate acne treatment. Even when I found a product giving some results – in the end my skin looked even worse or the results quickly disappeared. The worst part was shaving – my face was full of scratches, inflamed hair follicles and things like that. Infections also developed. In all this nonsense I recently read about a brand new product called Nonacne. I have not seen any reviews of this product before so I risked a little when buying it. But I do not regret my choice. Nonacne has a strong effect on my pimples. No new spots appear on my skin anymore and blackheads disappeared completely. Finally, my skin is soft and the razor blade is not my enemy anymore.
– Rob, Basingstoke
I am 32 years old and I have been struggling with the horror of acne since I was 20. So far, I have gone through like a million medical examinations that didn’t give any answers. My face has been one big experimental laboratory for different pills, antibiotics, creams and ointments that made my skin look even worse. Same with mechanical cleaning – scrubs, ultrasonic peels and a beautician – no results… I thought that perhaps I had not tried the simplest solution – a natural acne treatment. I have read that Nonacne contains lots of vitamins and herbal components so I decided to give it a try. And I was shocked – it helped! Perhaps not entirely as I have just started the treatment, but I see some results, which I previously did not see at all.
– Betty, Durham
For the last month I have used Nonacne and I must say that this product is great. Previously I spent huge amounts of money on other acne products and visits to a dermatologist. It did not give any results or the results didn’t last long. Since I started using Nonacne, no bigger pimples have appeared on my face. The improvement has been gradual but I eventually succeeded in winning the fight against acne! I intend to continue this acne treatment so I ordered further packages.
– Bart, Exeter
For me the problem of acne looked like this: no going out to parties, no drinking beer with friends, no eating pizza (it intensified the problem), not to mention: no dates. Total isolation. I was simply ashamed to be with people when I realized how advanced my acne was when I looked in the mirror. It was a nightmare. Of course, I have tried antibiotics (you cannot take antibiotics endlessly), various ointments and pills. It was a futile fight. I thought it was worth investing in something more expensive since you never know what might be effective. Nonacne caught my eye and I am not going to look for any other product. I will never replace it. In my case it worked wonders. I can finally start living a normal life. 🙂
– Alexandra, Ashford
MONEY BACK GUARANTEE
The efficacy of Nonacne has been repeatedly confirmed by numerous studies as well as satisfied customers. The Product is successful that the manufacturers have a money back guarantee in case you are not satisfied with the product.